Brain monoamine oxidase B and A in human parkinsonian dopamine deficiency disorders

Platelet monoamine oxidase B activity in parkinsonian patients.

Monoamine oxidase B (MAO B) plays a pivotal role in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced Parkinsonism. An increased MAO B activity in platelets of patients with idiopathic Parkinson's disease (PD) is reported in this study. The possibility that high MAO B activity may represent a trait of vulnerability for PD by enhancing the neurotoxic effects of environmental compounds ...

Visualization of monoamine oxidase in human brain.

11973 Monoamine oxidase (MAO; EC: 1.4.3.4) is a flavin containing enzyme which exists in two subtypes, MA0 A and MA0 B. MA0 A and B are different gene products and they also differ in their substrate and inhibitor selectivities and their cellular localizations. In human brain MA0 B predominates (B:A = 4:l) and is largely compartmentalized in cell bodies of serotonergic neurons and in glia. Many...

The relationship between human monoamine oxidase A and B

Monoamine oxidase (EC 1.4.3.4) exists in at least two forms (termed type A and type B) with different substrate and inhibitor specificities (Johnston, 1968; Knoll & Magyar, 1972). Amine neurotransmitters are among a wide range of substrates (Blaschko, 1974) and abnormalities of monoamine oxidase activity may therefore contribute to neurological disease. Most studies of such diseases have looked...

Adaptive changes in postsynaptic dopamine receptors despite unaltered dopamine dynamics in mice lacking monoamine oxidase B.

Monoamine oxidase (MAO) B is considered a key enzyme in dopamine metabolism. The present studies, conducted in MAO B knockout mice, show that lack of MAO B does not alter extracellular levels of dopamine in striatum. Similarly, the synthesis, storage, uptake, and release of dopamine are also unaltered. However, autoradiography revealed a significant up-regulation of the D2-like dopamine recepto...

Affective Disorders, Monoamine Oxidase and Chinese herbs